A novel efficient method for synthesis of propargylamines via three-component coupling of aryl azide, aldehyde, and alkyne promoted by iron-iodine-copper(I) bromide

作者：Zhang, Kui; Huang, You^*; Chen, Ruyu

来源：Tetrahedron Letters, 2010, 51(41): 5463-5465.

DOI：10.1016/j.tetlet.2010.08.024

• C-H ACTIVATION
• HIGHLY ENANTIOSELECTIVE SYNTHESIS
• ONE-POT SYNTHESIS
• SOLVENT-FREE CONDITIONS
• TERMINAL ALKYNES
• DIASTEREOSELECTIVE SYNTHESIS
• ALIPHATIC PROPARGYLAMINES
• CATALYZED SYNTHESIS
• REUSABLE CATALYST
• MANNICH REACTIONS

A novel, efficient method has been developed for the synthesis of propargylamines through a three-component coupling of aryl azides, aldehydes, and alkynes in the presence of iron-iodine-copper(I) bromide as catalyst. This method is the first example for directly using aryl azides as an amino component in a three-component coupling reaction. Some of the major advantages of this protocol are: good yields, the involvement of a less-expensive and non-toxic catalyst, mild reaction conditions, and a wide range of substrates.

• 出版日期2010-10-13
• 单位南开大学