Atropine Augmentation of Treadmill Exercise Stress Echocardiography

作者：Brenden Cynthia K; Eckman Peter M; Bruce Fane Lorrie; Erlien Darryl; Herzog Charles A^*

来源：Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques, 2011, 28(10): 1109-1112.

DOI：10.1111/j.1540-8175.2011.01482.x

• atropine
• chronotropic incompetence
• exercise
• stress echocardiography

Objectives: Performance of exercise stress testing depends on adequate workload and is limited by patients inability to reach target heart rate due to noncardiac illness or medications such as beta-blockers. This study aimed to assess the utility of atropine administration to augment the chronotropic response of patients undergoing treadmill exercise stress echocardiography. Methods: In a retrospective study, we assessed the utility of atropine administration to augment the chronotropic response in 1,396 patients undergoing treadmill exercise stress echocardiography between January 2004 and January 2009, compared with a historical control group with no atropine augmentation. Results: Atropine was well tolerated. The proportion of abnormal studies differed significantly between patients who underwent exercise with and without atropine augmentation (15% vs. 10%; P < 0.0001). Compared with the historical control group, the proportion of patients who achieved =85% of their target heart rates increased from 67% to 78% (P < 0.0001). Conclusions: While atropine augmentation is safe and feasible, further studies are required to determine whether it is an equivalent surrogate to achieving target heart rate through exercise alone. (Echocardiography 2011;28:1109-1112)

• 出版日期2011-11