A covariate-adjusted response-adaptive allocation in clinical trials for a general class of responses

作者：Bandyopadhyay Uttam; Bhattacharya Rahul^*

来源：Statistics in Medicine, 2013, 32(29): 5053-5061.

DOI：10.1002/sim.5900

• response-adaptive design
• covariate-adjusted allocation
• ethics

A class of covariate-adjusted adaptive allocation procedures is developed for a general class of responses with an aim to satisfy relevant clinical requirements. Some exact and asymptotic properties of the procedures, proposed and a reasonable competitor, are studied and compared under the presence of treatment-covariate interaction.

• 出版日期2013-12-20