Antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms

作者：Huang Chifu B^*; George Brian; Ebersole Jeffery L

来源：Archives of Oral Biology, 2010, 55(8): 555-560.

DOI：10.1016/j.archoralbio.2010.05.009

• Omega-6,-7,-9 (n-6, n-7, n-9) fatty acids
• Antimicrobial activity
• Fatty acid ethyl esters
• Fatty acid methyl esters

Objective. This study is to assess the antibacterial activity of omega-6, -7, -9 (n-6, n-7, n-9) fatty acids against various oral microorganisms
Methods The n-6, n-7, n-9 fatty acids, such as gamma-linoleic acid (GLA), linoleic acid (LA), arachidonic acid (ARA), palmitoleic acid (PA), and oleic acid (OA), their fatty acid ethyl esters, GLA-EE, LA-EE, ARA-EE, PA-EE, OA-EE, and their fatty acid methyl esters, GLA-ME, LA-ME, ARA-ME, PA-ME, OA-ME, were investigated for antimicrobial activity against oral pathogens Streptococcus mutans, Candida albicans, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, and Porphyromonas gingivalis Various concentrations of the fatty acids, their methyl and ethyl esters were tested against various oral pathogens in 96-well plates and blood-agar plate The plates were incubated anaerobically or aerobically at 37 degrees C for 48 h, and the colony forming units (CFU) were determined
Results The data demonstrated that select n-6, n-7, n-9 fatty acids and their esters exhibited strong antimicrobial activity against these oral microorganisms, demonstrating some specificity for individual microbial species
Conclusion The potential use or the combinations of the n-6, n-7, n-9 fatty acids and/or their esters,

• 出版日期2010-8