A contemporary cross-sectional study on dyslipidemia management, cardiovascular risk status, and patients%26apos; quality of life in Greece: The CHALLENGE study

作者：Alexopoulos Dimitrios; Anastasiou Nana Maria; Elisaf Moses S; Liberopoulos Evangelos; Rallidis Loukianos S; Davos Constantinos H; Moulis Alexandros; Nikas Nikos; Zacharis Evangelos; Vardas Panos

来源：International Journal of Cardiology, 2016, 217: 183-189.

DOI：10.1016/j.ijcard.2016.05.003

• LDL-C target
• ESC/EAS guidelines
• CV risk
• Quality of life
• Dyslipidemia guideline adherence

Background: Prior studies conducted in Greece consistently indicate that dyslipidemia is suboptimally managed, while the burden of cardiovascular disease (CVD) and related risk factors is rising.
Methods: CHALLENGE was a multicenter, cross-sectional study carried out following the publication of guidelines advocating stricter low-density lipoprotein cholesterol (LDL-C) targets. It primarily aimed to depict LDL-C target attainment, and to assess the cardiovascular risk status and quality of life (QoL) of patients treated in a primary or secondary CVD prevention setting who had received any medical intervention for cardiovascular risk modification within 6 months of enrollment.
Results: Between December 2012 and April 2013, 500 patients (55% males) aged (mean +/- SD) 62.0 +/- 11.7 years, participated in the study. Cardiovascular risk according to the 2011 European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines was 'very high', 'high', and 'moderate' in 61.2%, 23.4%, and 15.4%, respectively. Overall, 92.0% of patients were on lipid-lowering treatment, yet only 23.3% had attained their ESC/EAS-defined LDL-C target. LDL-C target attainment was more likely among 'moderate' versus 'very high' cardiovascular risk patients (odds ratio: 4.04; 95% confidence interval: 2.32-7.06; p < 0.001). QoL improved as cardiovascular risk decreased (EQ-VAS 71.8 +/- 16.2 in the 'very high' versus 78.3 +/- 15.1 and 80.3 +/- 15.7 in the 'high' and 'moderate' risk groups; p < 0.001). Time constraints and difficulties in implementation in daily practice were the investigator's main barriers for guideline utilization.
Conclusions: During contemporary management of dyslipidemia in Greece, LDL-C target attainment is suboptimal. There is an undoubted need for improvement and implementation of cardiovascular risk assessment in routine clinical practice.

• 出版日期2016-8-15