Association of hypoxia inducible factor-1 alpha polymorphisms with susceptibility to non-small-cell lung cancer

作者：Kuo Wu Hsien; Shih Chuen Ming; Lin Chiao Wen; Cheng Wei Erh; Chen Shuo Chueh; Chen Wei; Lee Yao Ling^*

来源：Translational Research, 2012, 159(1): 42-50.

DOI：10.1016/j.trsl.2011.09.003

Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a key regulator of cellular response to hypoxia and has been suggested to play an important role in tumorigenesis and metastasis. The aim of this study was to investigate the role of HIF-1 alpha-1772 C/T (P582S) and -1790 G/A (A588T) polymorphisms in the susceptibility to and severity of non-small-cell lung cancer (NSCLC). Using a case-control study design and polymerase chain reaction-restriction fragment-length polymorphism (PCR-RFLP) analysis, the allele frequencies and genotype distributions of each single nucleotide polymorphism in 285 NSCLC cases and 300 gender-matched controls were compared. The distribution of the genotype frequencies of HIF-1 alpha-1772 C/T and -1790 G/A were significantly different between the NSCLC and the controls. Logistic regression analysis revealed that higher odds ratios (ORs) for lung cancer were observed for individuals with HIFI 1 alpha-1772 T/T genotype against CC/CT genotypes (an OR of 4.04, 95% confidence interval (Cl) = 2.02-8.08, P = 0.0001), and HIF-1 alpha-1790 A/A genotype against GG/GA genotypes (an OR of 4.42, 95% CI 2.22-8.78, P %26lt; 0.0001). There were no relationship between HIF-1 alpha-1772 C/T or -1790 G/A allele distribution and disease severity of NSCLC (P %26gt; 0.05). However, those patients carrying a HIF-1 alpha-1772 T/T genotype or a HIF-1 alpha-1790 A/A had a tendency toward inferior prognosis compared with other patients. (Translational Research 2012;159:42-50)

• 出版日期2012-1
• 单位中国医科大学