Association of beta(2)-Adrenergic Receptor Polymorphisms with Asthma in a North Indian Population

作者：Birbian Niti; Singh Jagtar^*; Jindal Surinder Kumar; Singla Neha

来源：Lung, 2012, 190(5): 497-504.

DOI：10.1007/s00408-012-9407-7

• Asthma
• beta(2)-Adrenergic receptor (beta(2)AR)
• beta(2)AR-16 and beta(2)AR-27 gene polymorphisms
• North Indian population
• PCR-RFLP

beta(2)-Adrenergic receptor (beta(2)AR), a G-protein coupled receptor, is present on the bronchial smooth muscle cells and results in bronchodilation upon activation. The genetic factors determining beta(2)AR expression and function may not only alter the response of an individual to the therapy but also may serve as predictive markers for response to the agonists used in the therapy. The present study aimed at evaluating the role of beta(2)AR-16 and beta(2)AR-27 gene polymorphisms in asthma. %26lt;br%26gt;A case-control study was performed with a total of 824 adult subjects, including 410 asthmatics and 414 healthy controls from regions of North India. The beta(2)AR-16 and beta(2)AR-27 polymorphisms were genotyped by PCR-RFLP. %26lt;br%26gt;Statistical analysis for the beta(2)AR-16 polymorphism revealed that the mutant Gly16 allele was significantly associated with asthma, with OR = 0.80, 95 % CI = 0.65-0.99, and P = 0.032. The Gly16/Gly16 mutant genotype also confers decreased risk toward asthma, with OR = 0.65, 95 % CI = 0.41-1.02, and P = 0.049. However, the beta(2)AR-27 polymorphism was not associated with asthma as it did not reach statistical significance, with OR = 0.86, 95 % CI = 0.69-1.07, and P = 0.163. %26lt;br%26gt;The beta(2)AR-16 polymorphism confers a decreased risk toward asthma while the beta(2)AR-27 polymorphism is not associated with asthma in the studied North Indian population.

• 出版日期2012-10