HHEX-IDE Polymorphism Is Associated with Low Birth Weight in Offspring with a Family History of Type 1 Diabetes

作者：Winkler Christiane; Illig Thomas; Koczwara Kerstin; Bonifacio Ezio; Ziegler Anette Gabriele^*

来源：Journal of Clinical Endocrinology & Metabolism, 2009, 94(10): 4113-4115.

DOI：10.1210/jc.2009-0970

Context: The fetal insulin hypothesis proposes that common genetic variants that reduce insulin secretion also reduce birth weight, and an association of low birth weight and the type 2 diabetes risk alleles at the HHEX-IDE and CDKAL1 loci were recently reported.
Objective: Here, we examined the relationship between type 2 diabetes risk alleles and birth weight in a diabetic environment presented in children of mothers with type 1 diabetes.
Research Design and Methods: Birth weight and genotyping of single nucleotide polymorphisms (SNPs) at the CDKAL1, HHEX-IDE, and SLC30A8 loci was obtained and analyzed in 729 singleton full-term children of mothers with type 1 diabetes born in Germany.
Results: The fetal risk alleles of HHEX-IDE SNP rs5015480 and SNP rs10882102 were associated with reduced birth weight: 81 g (95% confidence interval, 20-140 g; P = 0.009) and 85 g (95% confidence interval, 25-145 g; P = 0.005) lower birth weight per risk allele, respectively. The association remained significant after adjusting for maternal pregnancy-glycosylated hemoglobin. Fetal genotypes at the CDKAL1 and SLC30A8 loci were not associated with birth weight in this cohort.
Conclusions: The association of low birth weight and type 2 diabetes risk alleles of the HHEX-IDE locus is confirmed in children of mothers with type 1 diabetes. (J Clin Endocrinol Metab 94: 4113-4115, 2009)

• 出版日期2009-10