Androgen inhibition of sexual receptivity is modulated by estrogen

作者：Kirkpatrick Meg E^*; Clark Ann S

来源：Physiology & Behavior, 2011, 102(3-4): 361-366.

DOI：10.1016/j.physbeh.2010.11.033

• Sexual behavior
• Androgens
• Estrogen
• Lordosis
• Inhibition

Sexual receptivity induced in ovariectomized rats by the long-term administration of estradiol benzoate (EB) can be inhibited by concurrent administration of androgens. Experiment 1 examined the role of time course and dose of androgens in the inhibition of estrogen-induced sexual receptivity. Ovariectomized rats were treated with EB (2.0 mu g per rat per day) for 6 days and tested for sexual receptivity (Test Day l). EB treatment continued for 15 days concomitant with daily administration of one of three doses of dihydrotestosterone propionate (DHTP: 7.5, 0.75, 0.075 mg/kg) or 3 alpha-androstanediol (3 alpha-Adiol; 3.75, 1.0, 0.375 mg/kg). Four tests for sexual receptivity were conducted on days 3, 6, 14, and 15 of the androgen/vehicle treatment period (Test Days II-V). On Day 15 (Test Day V), the rats received progesterone (1.0 mg per rat) 4 h before testing. Using the same experimental design, Experiment 2 examined the effect of increasing the dose of estrogen on the androgenic inhibition of sexual receptivity. Ovariectomized rats were treated with one of two doses of EB (2.0 or 10.0 mu g per rat per day) concomitant with daily administration of DHTP (7.5 mg/kg) or 3 alpha-Adiol (3.75 mg/kg). In Experiment 1, the highest doses of both DHTP and 3 alpha-Adiol significantly inhibited estrogen-induced sexual receptivity. Data from Experiment 2 indicate that the inhibitory effects of DHTP but not 3 alpha-Adiol call be moderated by an increased dose of EB.

• 出版日期2011-3-1