Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin

作者:Maoka Takashi*; Yasui Hiroyuki; Ohmori Aya; Tokuda Harukuni; Suzuki Nobutaka; Osawa Ayako; Shindo Kazutoshi; Ishibashi Takashi
来源:Journal of Oleo Science, 2013, 62(3): 181-186.
DOI:10.5650/jos.62.181

摘要

Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin, which are biosynthetic intermediates from beta-carotene to astaxanthin, were investigated. Both adonirubin and adonixanthin showed almost the same activities for inhibition of lipid peroxidation and quenching of singlet oxygen as those of astaxanthin. Furthermore, adonirubin and adonixanthin exhibited an inhibitory effect on Epstein-Barr virus early antigen activation in Raji cells and carcinogensis of mouse skin tumors initiated by 7,12-dimethylbenz[a]anthracene and promoted by 12-O-tetradecanoylphorbol-13-acetate.

  • 出版日期2013-3