n-3 Polyunsaturated fatty acids ameliorate cognitive age-related impairments and depressive behaviour in unchallenged aged prediabetic rats

作者：Guo Yu Ru; Hsu Yi Hao; Liang An; Lu Wan Jung; Wu Chi Hao; Lee Hsiu Chuan; Huang Shih Yi

来源：Journal of Functional Foods, 2015, 19: 522-536.

DOI：10.1016/j.jff.2015.09.050

• Fatty acid
• Cognitive impairment
• Depression

Epidemiological studies have reported that nutritional deficit of n-3 polyunsaturated fatty acids (PUFAs) is closely related to depression and cognitive impairment in middle and later life. This study investigated the preventive effects of n-3 PUFA-rich oils on the behavioural impairment of unchallenged aged prediabetic rats by using a Morris water maze (MWM) test and forced swimming test (FST). Twenty 102-wk-old male SD male rats received a 35% sucrose solution and were fed with fish oil or flaxseed oil diets for 8 wk. Both treatments reduced the production of IL-6 and non-esterified fatty acids significantly. Both treatments demonstrated significantly quicker MWM acquisition, shorter FST immobility time and higher levels of nerve growth factor than did the control group. Thus, n-3 PUFA-rich oil might produce protective effects by improving fasting blood sugar levels and reducing proinflammatory cytokine levels, thus preventing cognitive age-related impairments and depression-like behaviour in aged prediabetic rats.

• 出版日期2015-12