Cerebrospinal Fluid Anti-Amyloid-beta Autoantibodies and Amyloid PET in Cerebral Amyloid Angiopathy-Related Inflammation

作者：Carmona Iragui Maria; Fernandez Arcos Ana; Alcolea Daniel; Piazza Fabrizio; Morenas Rodriguez Estrella; Anton Aguirre Sofia; Sala Isabel; Clarimon Jordi; Dols Icardo Oriol; Camacho Valle; Sampedro Frederic; Munuera Josep; Nunez Marin Fidel; Lleo Alberto; Fortea Juan^*; Gomez Anson Beatriz; Blesa Rafael

来源：Journal of Alzheimer's Disease, 2016, 50(1): 1-7.

DOI：10.3233/JAD-150614

• Biomarkers
• cerebral amyloid angiopathy
• cerebrospinal fluid
• Florbetapir-PET
• inflammation

We report a biomarker and genetic evaluation of four patients with cerebral amyloid angiopathy-related inflammation (CAA-ri) treated with corticosteroids. Patients presented with focal symptomatology and cognitive impairment. MRI revealed cortical microbleeds and asymmetrical hyperintense white matter lesions (WML). Cerebrospinal fluid (CSF) biomarker analyses showed increased anti-A beta autoantibodies, t-Tau, and p-Tau and decreased A beta(40) and A beta(42). After treatment, focal symptomatology disappeared, and WML and anti-A beta autoantibodies decreased. The APOE epsilon 4 allele was overrepresented. Florbetapir-PET showed cortical deposition with lower retention in swollen areas. In the case of suspected CAA-ri, both CSF anti-A beta autoantibodies levels and Florbetapir-PET could provide highly useful data to guide the correct diagnosis.

• 出版日期2016