Design of chondroitin sulfate-based polyelectrolyte nanoplexes: Formation of nanocarriers with chitosan and a case study of salmon calcitonin

作者：Umerska Anita; Corrigan Owen I; Tajber Lidia

来源：Carbohydrate Polymers, 2017, 156: 276-284.

DOI：10.1016/j.carbpol.2016.09.035

• Chondroitin sulfate
• Chitosan
• Nanoparticles
• Polyelectrolyte complexes
• Calcitonin
• Peptide

The aim of this work was to examine the formation and properties of chondroitin sulfate (CHON)-based nanoparticles (NPs), namely CHON/chitosan (CHIT), CHON/CHIT/calcitonin (sCT) and CHON/sCT. Both, positively and negatively charged CHON/CHIT NPs have been successfully obtained with properties that were dependent on the polymer mixing ratio, polymer concentration and molecular weight of CHIT. sCT was successfully loaded into CHON/CHIT NPs with efficiency close to 100% and notably high loading (up to 33%). A new type of NPs composed of CHON and sCT (a binary system) has been successfully developed. CHON/sCT NPs offer the advantage of a very high drug loading up to 73%. The particle size of CHON-based NPs increased in PBS, acetate buffer and in HC1 solution compared to that in water, but most of them remained in the nano-range even after 24 h. The media and composition of the nanocarriers were found to affect the release of sCT.

• 出版日期2017-1-20