INFLUENCE OF I/D POLYMORPHISM OF THE ACE GENE ON PEH IN NORMOTENSIVE YOUNG MEN

作者：Fernandes Manuella de Oliveira; Azevedo Luan Morais; Dolabella Silvio Santana; Pardono Emerson^*

来源：Revista Brasileira de Medicina do Esporte, 2015, 21(4): 308-312.

DOI：10.1590/1517-869220152104137628

• exercise
• post-exercise hypotension
• angiotensin converting enzyme
• arterial pressure

Introduction: The post-exercise hypotension (PEH) is considered a non-pharmacological strategy adopted for lowering blood pressure (BP). Moreover, it is known that the presence of some genetic polymorphisms, such as the I/D of the angiotensin converting enzyme (ACE) gene, can influence the blood pressure response. Objective: Analyze the influence of the ACE I/D polymorphism on PEH after three different exercise intensities in normotensive and physically active young people. Methods: Twenty-six healthy young men (DD=11; ID/II=15) performed a maximal 1600 meters running session in a athletics track and another three experimental sessions (Moderate Session: 6% below the anaerobic threshold, Intense Session: 6% above the anaerobic threshold, and a Control Session) with previous measurements of BP for 20 minutes and after the exercise for 60 minutes. Results: It was observed that moderate exercise has brought on PEH, regardless of genotype group, being more evident for systolic blood pressure at 45 minutes and 60 minutes (p <= 0.05). It was also found that the genic characteristics has influence on the area under the pressure curve (p <= 0.005) for the diastolic blood pressure, formed 1 hour after exercise. Conclusion: It is concluded that moderate exercise causes PEH in normotensive and physically active young men, regardless of I/D polymorphism in the ACE gene, that this polymorphism influences the diastolic blood pressure, and that subjects with the I allele have a greater drop in diastolic BP (DBP).

• 出版日期2015-8