Air pollution, oxidative damage to DNA, and carcinogenesis

作者：Moller Peter^*; Folkmann Janne Kjaersgaard; Forchhammer Lykke; Brauner Elvira Vaclavik; Danielsen Pernille Hogh; Risom Lotte; Loft Steffen

来源：Cancer Letters, 2008, 266(1): 84-97.

DOI：10.1016/j.canlet.2008.02.030

• biomonitoring
• comet assay
• cancer
• DNA damage
• particulate matter

There is growing concern that air pollution exposure increases the risk of lung cancer. The mechanism of action is related to particle-induced oxidative stress and oxidation of DNA. Humans exposed to urban air with vehicle emissions have elevated levels of oxidized guanine bases in blood cells and urine. Animal experimental studies show that pulmonary and gastrointestinal exposure is associated with elevated levels of oxidized guanines in the lung and other organs. Collectively, there is evidence indicating that exposure to traffic-related air pollution particles is associated with oxidative damage to DNA and this might be associated with increased risk of cancer.

• 出版日期2008-7-18