A man-made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother

作者：Barg Assaf Arie^*; Ifrah Aviya Dvir; Strauss Tzipi; Simchen Michal J; Orvieto Raoul; Rosenberg Nurit; Kenet Gili

来源：Pediatric Blood and Cancer, 2017, 64(8): e26447.

DOI：10.1002/pbc.26447

• HPA
• neonatal thrombocytopenia
• oocyte donor
• surrogate pregnancy
• Turner syndrome

The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the first report of FNAIT in which the suggested mechanism involves antibodies produced by a gestational mother against the incompatible HPA of the oocyte donor.

• 出版日期2017-8