Mitochondrial complex II and genomic imprinting in inheritance of paraganglioma tumors

作者：Baysal Bora E^*

来源：Biochimica et Biophysica Acta-Bioenergetics, 2013, 1827(5): 573-577.

DOI：10.1016/j.bbabio.2012.12.005

• Mitochondrial complex II
• Succinate dehydrogenase
• Paraganglioma
• Imprinting
• SDHD

Germ line heterozygous mutations in the structural subunit genes of mitochondrial complex II (succinate dehydrogenase; SDH) and the regulatory gene SDHAF2 predispose to paraganglioma tumors which show constitutive activation of hypoxia inducible pathways. Mutations in SDHD and SDHAF2 cause highly penetrant multifocal tumor development after a paternal transmission, whereas maternal transmission rarely, if ever, leads to tumor development. This transmission pattern is consistent with genomic imprinting. Recent molecular evidence supports a model for tissue-specific imprinted regulation of the SDHD gene by a long range epigenetic mechanism. In addition, there is evidence of SDHB mRNA editing in peripheral blood mononuclear cells and long-term balancing selection operating on the SDHA gene. Regulation of SDH subunit expression by diverse epigenetic mechanisms implicates a crucial dosage-dependent role for SDH in oxygen homeostasis. This article is part of a Special Issue entitled: Respiratory complex Role in cellular physiology and disease.

• 出版日期2013-5