A novel isoform of the Ly108 gene ameliorates murine lupus

作者:Keszei Marton; Detre Cynthia; Rietdijk Svend T; Munoz Pilar; Romero Xavier; Berger Scott B; Calpe Silvia; Liao Gongxian; Castro Wilson; Julien Aimee; Wu Ying Yu; Shin Dong Mi; Sancho Jaime; Zubiaur Mercedes; Morse Herbert C III; Morel Laurence; Engel Pablo; Wang Ninghai; Terhorst Cox*
来源:Journal of Experimental Medicine, 2011, 208(4): 811-822.
DOI:10.1084/jem.20101653

摘要

Studies of human systemic lupus erythematosus patients and of murine congenic mouse strains associate genes in a DNA segment on chromosome 1 with a genetic predisposition for this disease. The systematic analysis of lupus-prone congenic mouse strains suggests a role for two isoforms of the Ly108 receptor in the pathogenesis of the disease. In this study, we demonstrate that Ly108 is involved in the pathogenesis of lupus-related auto-immunity in mice. More importantly, we identified a third protein isoform, Ly108-H1, which is absent in two lupus-prone congenic animals. Introduction of an Ly108-H1-expressing transgene markedly diminishes T cell-dependent autoimmunity in congenic B6.Sle1b mice. Thus, an immune response-suppressing isoform of Ly108 can regulate the pathogenesis of lupus.

  • 出版日期2011-4-11