Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata

作者：Tsurumi Fumika; Miura Yuta; Saito Yohei; Miyake Katsunori; Fujie Tetsuo; Newman David J; O'Keefe Barry R; Lee Kuo Hsiung; Nakagawa Goto Kyoko

来源：Organic Letters, 2018, 20(8): 2282-2286.

DOI：10.1021/acs.orglett.8b00624

Six novel lactone derivatives, cryptolaevilactones A-F (1-6), were isolated from Cryptocarya laevigata. Their unique spiro[3.5]nonane moiety by hetero [2 + 2] cyclization with monoterpene and polyketide was found for the first time in nature. Structural elucidation using various nuclear magnetic resonance (NMR) techniques revealed that 1-3 and 4-6 are diastereomers and partially established the absolute configurations.

• 出版日期2018-4-20