Acute Ibuprofen Intoxication Report on a Case and Review of the Literature

作者：Lodise Maria; De Giorgio Fabio^*; Rossi Riccardo; d' Aloja Ernesto; Fucci Nadia

来源：American Journal of Forensic Medicine and Pathology, 2012, 33(3): 242-246.

DOI：10.1097/PAF.0b013e318253d6ff

• ibuprofen
• acute intoxication
• forensic autopsy
• gas chromatography/mass spectrometry
• nonsteroidal anti-inflammatory drug
• postmortem investigation

A fatality following the ingestion of ibuprofen is reported. Ibuprofen is a prototypical nonsteroidal anti-inflammatory drug widely prescribed as an analgesic, anti-inflammatory, and antipyretic agent. To date, there are few case reports of fatal overdose with ibuprofen, following ibuprofen self-poisoning or accidental overdose. We report the case of a 51-year-old man with medical history of psychiatric disease, who was brought to the emergency department by ambulance with a chief complaint of having taken large amounts of drugs in a suicide attempt. %26lt;br%26gt;Multiple empty containers of medications (ibuprofen, meloxicam, celecoxib, risperidone, citalopram, ketorolac, bromazepam) were found at the scene. He died 4 hours after admission to the emergency department, despite vigorous supportive care. Toxicological analyses were performed using a gas chromatography/mass spectrometry technique. The estimated ibuprofen concentration in the plasma was 600 mu g/mL; gastric content was 200 mu g/mL for this compound. Our report describes results of the forensic investigation and discuss the review of the literature.

• 出版日期2012-9