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摘要
AimAttention-deficit-hyperactivity disorder (ADHD) is a disorder that is associated with accidental injuries. The aim of this study was to evaluate the relationship between ADHD and bone fracture in children. %26lt;br%26gt;MethodThe study cohort comprised 3640 children (2874 males, 766 females; mean age 8y 5mo, SD 3y) with ADHD (International Classification of Diseases, Ninth Revision) who were matched to children without ADHD at a ratio of 1:4 (n=14 560; 11 496 males, 3064 females; mean age 8y 5mo, SD 3y). A Cox proportional hazard regression analysis was conducted to estimate how ADHD affected the risk of bone fracture. %26lt;br%26gt;ResultsThe incidence of fracture among the ADHD cohort was 197.67 per 10000 person-years, and was 1.3-fold greater than in the comparison cohort (147.54 per 10000 person-years). The risk in children with ADHD was higher than that in children without ADHD (p value for log-rank test %26lt; 0.001). After adjusting for potential confounding factors, the ADHD cohort was 1.32 times more likely to have bone fracture accidents than the comparison cohort (hazard ratio, 1.32; 95% confidence interval 1.17-1.49). %26lt;br%26gt;InterpretationChildren with ADHD have a higher risk of experiencing bone fracture accidents than do children without ADHD. %26lt;br%26gt;What this paper adds %26lt;br%26gt;%26lt;list list-type=%26quot;bulleted%26quot; id=%26quot;dmcn12501-list-0001%26quot;%26gt;The risk of bone fracture accidents was significantly higher among children with attention-deficit-hyperactivity disorder (ADHD) than among children without ADHD.After adjusting for potential confounding factors, those in the ADHD cohort were 1.32 times more likely to experience bone fracture accidents than those in the comparison cohort. %26lt;br%26gt;This article is commented on by Cairney on pages 1040-1041 of this issue.
- 出版日期2014-11
- 单位中国医科大学
