Alnuheptanoid A: a new diarylheptanoid derivative from Alnus japonica

作者：Ibrahim Sabrin R M^*; Fouad Mostafa A; Abdel Lateff Ahmed; Okino Tatsufumi; Mohamed Gamal A

来源：Natural Product Research, 2014, 28(20): 1765-1771.

DOI：10.1080/14786419.2014.947489

• Alnus japonica
• Betulaceae
• alnuheptanoid A
• diarylheptanoids
• triterpenoids
• sterols

Extensive chromatographic investigation of the ethanolic extract of Alnus japonica Steud stem bark led to the isolation of a new diarylheptanoid named alnuheptanoid A [(5S)-7-(3,4-dihydroxyphenyl)-1-(4-hydroxyphenyl)-5-methoxyheptan-3-one] (8), together with seven known diarylheptanoid derivatives: platyphyllenone (5), (5S)-1,7-bis(4-hydroxyphenyl)-5-methoxyheptan-3-one (6), 1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-4-hepten-3-one (7), hirsutenone (9), (5R)-O-methylhirsutanonol (10), hirsutanonol (11) and oregonin (13), three triterpenes: a-amyrin (1), betulinaldehyde (3) and betulinic acid (4), and two sterols: b-sitosterol (2) and daucosterol (12). Compound 6 was isolated for the first time from natural source. The structures of the isolated compounds were determined on the basis of spectroscopic measurements (UV, IR, HR-ESI-MS, 1D and 2D NMR).

• 出版日期2014