Anti-arthritic Active Fraction of Capparis Spinosa L. Fruits and Its Chemical Constituents

作者：Feng, Xiaolu; Lu, Jincai; Xin, Hailiang; Zhang, Lei; Wang, Yuliang^*; Tang, Kexuan

来源：Journal of the Pharmaceutical Society of Japan, 2011, 131(3): 423-429.

DOI：10.1248/yakushi.131.423

• Capparis spinosa L. (Capparidaceae)
• arthritic
• stachydrine

The aim of this study was to ascertain the anti-arthritic active fraction of Capparis spinosa L. (Capparidaceae) fruits and its chemical constituents. The adjuvant arthritic rat model was developed to evaluate the anti-arthritic effects of different fractions of ethanol extraction from C. spinosa L. The fraction eluted by ethanol-water (50 : 50, v/v) had the most significant anti-arthritic activity. The chemical constituents of this fraction were therefore studied; seven known compounds were isolated and identified as: (1) P-hydroxy benzoic acid; (2) 5- (hydroxymethyl) furfural; (3) bis (5-formylfurfuryl) ether; (4) daucosterol; (5) alpha-D-fructofuranosides methyl; (6) uracil; and (7) stachydrine.

• 出版日期2011-3
• 单位上海交通大学; 中国人民解放军第二军医大学; 沈阳药科大学