A case of sulphasalazine potentiating the hypoprothombinemic effect of warfarin resulting in bleeding

作者：Hall S; Rindone J P^*

来源：Journal of Clinical Pharmacy and Therapeutics, 2011, 36(2): 246-248.

DOI：10.1111/j.1365-2710.2010.01173.x

• interaction
• sulphasalazine
• warfarin

P>What is known and Objective:
One case report demonstrated warfarin resistance associated with sulphasalazine therapy. Our objective is to report on a case of warfarin potentiation rather than resistance, associated with sulphasalazine therapy.
Case summary:
The patient was taking warfarin for two mechanical heart valves and was prescribed sulphasalazine for inflammatory bowel disease. He had stable international normalized ratios (INRs) before sulphasalazine administration. Approximately 3 weeks after starting sulphasalazine, he presented to the anticoagulation clinic with bruising and an INR of 6 center dot 1. The sulphasalazine was stopped, and the warfarin was held for 3 days; then the previous dose was resumed. Three weeks later, the INR returned to a therapeutic level.
What is new and Conclusion:
This is the first case of sulphasalazine potentiating the effect of warfarin. Sulphasalazine may potentiate the hypoprothombinemic effect of warfarin.

• 出版日期2011-4