A NOVEL DAPHNANE-TYPE DITERPENE FROM THE FLOWER BUD OF Daphne genkwa

作者：Li, L. Z.^*; Gao, P. Y.; Peng, Y.; Wang, L. H.; Song, S. J.

来源：Chemistry of Natural Compounds, 2010, 46(3): 380-382.

DOI：10.1007/s10600-010-9622-5

• Daphne genkwa
• daphnane-type diterpene
• structure elucidation
• HL-60 cells

A novel daphnane-type diterpene, genkwanin I (1), and a novel natural product, orthobenzoate 2 (2), were isolated from the flower bud of Daphne genkwa. The structures of the two compounds were elucidated by spectral techniques, viz. 1D, 2D NMR spectra and HR-ESI-MS. Genkwanin I showed inhibitory activity against human promyelocytic HL-60 cells at an IC(50) level of 11.74 mu M.

• 出版日期2010-7
• 单位沈阳药科大学