Toll-like receptors recognize distinct proteinase-resistant glycoconjugates in Campylobacter jejuni and Escherichia coli

作者：Phongsisay Vongsavanh^*; Hara Hiromitsu; Fujimoto Shuji

来源：Molecular Immunology, 2015, 64(1): 195-203.

DOI：10.1016/j.molimm.2014.11.020

• Campylobacter jejuni
• Inflammation
• Toll-like receptors

Campylobacter jejuni causes gastroenteritis and autoimmune neuropathy Guillain Barre syndrome. The mechanism by which C. jejuni infection results in such the hyperimmunity is not completely understood. Host immunity plays an important role in the disease pathogenesis; however, little is known how immune system recognizes this human pathogen. In this study, we report that Toll-like receptors recognize distinct proteinase K-resistant glycoconjugates in C. jejuni and Escherichia coli. Lipopolysaccharide is solely proteinase-resistant glycoconjugate in E. coli. In contrast, C. jejurti possesses at least five different components that are resistant to proteinase digestion and are capable of inducing NF-kappa B activation through TLR2 and TLR4. Possession of multiple activators of Toll-like receptors may be the unique strategy of C jejuni to trigger hyperimmunity.

• 出版日期2015-3