Diets rich in fruits and vegetables suppress blood biomarkers of metabolic stress in overweight women

作者：Yeon Jee Young; Kim Hyun Sook; Sung Mi Kyung^*

来源：Preventive Medicine, 2012, 54: S109-S115.

DOI：10.1016/j.ypmed.2011.12.026

• Overweight women
• Vegetable-fruit diet
• Inflammation biomarkers
• Oxidative stress biomarkers

Objective. This study was performed to evaluate the effects of high vegetable-fruit (high-VF) and low vegetable-fruit (low-VF) diet on surrogate biomarkers of adiposity-related metabolic disturbances.
Methods. Overweight women (n = 22, 19-29 years) participated in the study between July and August, 2007 in Seoul, Korea. The intervention consisted of either high-VF diet (12 servings of VF/day) or low-VF diet (2 servings of VF/day). Plasma concentration of carotenoids and biomarkers of inflammation and oxidative stress were determined before and after each intervention period.
Results. Study results indicated that body fat content is positively correlated with plasma interleukin (IL)-6. C-reactive protein (CRP), and leptin concentrations at baseline. Oxidative DNA damage and lipo-polysaccharide (LPS)-activated production of IL-1 beta and IL-6 in peripheral blood mononuclear cells (PBMCs) were decreased with high-VF diet while low-VF diet increased those markers. Changes in the concentration of plasma total carotenoid and beta-carotene were inversely correlated with change in plasma IL-1 beta concentration. Differences in IL-beta production in LPS-activated PBMCs were inversely correlated with changes in plasma concentration of lutein-zeaxanthin. Also, changes in plasma total carotenoid and lycopene concentration were inversely correlated with the changes in IL-6 production in LPS-activated PBMCs.
Conclusion. Daily intake of vegetables and fruits can modify adiposity-related metabolic disturbances.

• 出版日期2012-5-1