A dual-FRET-based fluorescence probe for the sequential detection of MMP-2 and caspase-3

作者:Li Shi Ying; Liu Li Han; Cheng Hong; Li Bin; Qiu Wen Xiu; Zhang Xian Zheng
来源:Chemical communications, 2015, 51(77): 14520-14523.
DOI:10.1039/c5cc04962h

摘要

A novel dual-FRET-based fluorescence probe was designed and synthesized for the sequential detection of MMP-2 and caspase-3. This probe can successfully monitor Dox- and UV-induced cell apoptosis signals in real time and in situ, which demonstrated its great potential for apoptosis-related drug screening and dynamic apoptosis imaging.