Upper gastrointestinal complications associated with gemcitabine-concurrent proton radiotherapy for inoperable pancreatic cancer

作者：Takatori Kento^*; Terashima Kazuki; Yoshida Rihito; Horai Aya; Satake Shinya; Ose Takayuki; Kitajima Naoto; Kinoshita Yoshikazu; Demizu Yusuke; Fuwa Nobukazu

来源：Journal of Gastroenterology, 2014, 49(6): 1074-1080.

DOI：10.1007/s00535-013-0857-3

• Proton radiotherapy
• Pancreatic cancer
• Radiation ulcer

Little is known about acute upper gastrointestinal (GI) complications associated with gemcitabine-concurrent proton radiotherapy (GPT) for inoperable pancreatic cancer. We investigated acute GI complications following GPT in patients with inoperable pancreatic cancer using small-bowel endoscopy. %26lt;br%26gt;This prospective single center observational study was conducted at the Hyogo Ion Beam Medical Center from January 2010 to January 2012. Ninety-one patients who had clinically and medically inoperable pancreatic cancer treated by GPT were analyzed. Endoscopic examinations were performed before and after GPT to clarify the incidence rates of radiation-induced ulcers, GI hemorrhage, and GI perforation associated with GPT. %26lt;br%26gt;Post-treatment endoscopic examinations revealed that 45 (49.4 %) patients had radiation-induced ulcers in the stomach and duodenum. Of those, many ulcerative lesions were found in the lower stomach (51 %) and horizontal part of the duodenum (39 %), regardless of the primary tumor site in the pancreas. Neither GI hemorrhage, nor perforation, was found in post-treatment endoscopy examinations. %26lt;br%26gt;Approximately half of the patients treated with GPT for inoperable pancreatic cancer exhibited radiation-induced ulcers in the stomach and duodenum.

• 出版日期2014-6