Ni-Catalyzed C-C Couplings Using Alkyl Electrophiles

作者：Iwasaki Takanori; Kambe Nobuaki^*

来源：Topics in Current Chemistry, 2016, 374(5): UNSP 66.

DOI：10.1007/s41061-016-0067-6

• Cross-coupling
• Homogeneous catalysis
• Nickel
• Alkyl halides
• Organometallic reagents

Much effort has been devoted to developing new methods using Ni catalysts for the cross-coupling reaction of alkyl electrophiles with organometallic reagents, and significant achievements in this area have emerged during the past two decades. Nickel catalysts have enabled the coupling reaction of not only primary alkyl electrophiles, but also sterically hindered secondary and tertiary alkyl electrophiles possessing beta-hydrogens with various organometallic reagents to construct carbon skeletons. In addition, Ni catalysts opened a new era of asymmetric cross-coupling reaction using alkyl halides. Recent progress in nickel-catalyzed cross-coupling reaction of alkyl electrophiles with sp(3)-, sp(2)-, and sp-hybridized organometallic reagents including asymmetric variants as well as mechanistic insights of nickel catalysis are reviewed in this chapter.

• 出版日期2016-10