科研之友
微信
新浪微博
Facebook
分享链接
摘要
Background: Magnetic resonance imaging (MRI) is widely used in several muscle disorders. Diffusion-weighted imaging (DWI) is an imaging modality, which can reflect microstructural tissue composition. The apparent diffusion coefficient (ADC) is used to quantify the random motion of water molecules in tissue.
Purpose: To investigate ADC values in patients with myositis and non-inflammatory myopathy and to analyze possible associations between ADC and laboratory parameters in these patients.
Material and Methods: Overall, 17 patients with several myositis entities, eight patients with non-inflammatory myopathies, and nine patients without muscle disorder as a control group were included in the study (mean age = 55.3 +/- 14.3 years). The diagnosis was confirmed by histopathology in every case. DWI was obtained in a 1.5-T scanner using two b-values: 0 and 1000 s/mm(2). In all patients, the blood sample was acquired within three days to the MRI. The following serological parameters were estimated: C-reactive protein, lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, creatine kinase, and myoglobine.
Results: The estimated mean ADC value for the myositis group was 1.89 +/- 0.37 x 10(-3) mm(2)/s and for the non-inflammatory myopathy group was 1.79 +/- 0.33 x 10(-3) mm(2)/s, respectively. The mean ADC values (1. 15 +/- 0.37 x 10(-3) mm(2)/s) were significantly higher to unaffected muscles (vs. myositis Rho = 0.0002 and vs. myopathy Rho = 0.0021). There were no significant correlations between serological parameters and ADC values.
Conclusion: Affected muscles showed statistically significantly higher ADC values than normal muscles. No linear correlations between ADC and serological parameters were identified.
- 出版日期2018-6
