Arylsulfonyl acridinyl derivatives acting on Plasmodium falciparum

作者：Santelli Rouvier C^*; Pradines B; Berthelot M; Parzy D; Barbe J

来源：European Journal of Medicinal Chemistry, 2004, 39(9): 735-744.

DOI：10.1016/j.ejmech.2004.05.007

• acridinic sulfone
• Plasmodium falciparum
• PABA

Several arylacridinyl sulfones have been synthesized and their antimalarial action was tested on Plasmodium falciparum. PABA (para-aminobenzoic acid) has no antagonistic effect with these compounds as opposed to the observed effect with dapsone and sulfonamides previously studied. A possible relationship between the ability of cleavage of the S-9C acridinic bond and activity is suggested.

• 出版日期2004-9