Acquisition of natural humoral immunity to P. falciparum in early life in Benin: impact of clinical, environmental and host factors

作者：Dechavanne Celia^*; Sadissou Ibrahim; Bouraima Aziz; Ahouangninou Claude; Amoussa Roukiyath; Milet Jacqueline; Moutairou Kabirou; Massougbodji Achille; Theisen Michael; Remarque Edmond J; Courtin David; Nuel Gregory; Migot Nabias Florence; Garcia Andre

来源：Scientific Reports, 2016, 6(1): 33961.

DOI：10.1038/srep33961

To our knowledge, effects of age, placental malaria infection, infections during follow-up, nutritional habits, sickle-cell trait and individual exposure to Anopheles bites were never explored together in a study focusing on the acquisition of malaria antibody responses among infants living in endemic areas. Five hundred and sixty-seven Beninese infants were weekly followed-up from birth to 18 months of age. Immunoglobulin G (IgG), IgG1 and IgG3 specific for 5 malaria antigens were measured every 3 months. A linear mixed model was used to analyze the effect of each variable on the acquisition of antimalarial antibodies in 6- to 18-month old infants in univariate and multivariate analyses. Placental malaria, nutrition intakes and sickle-cell trait did not influence the infant antibody levels to P. falciparum antigens. In contrary, age, malaria antibody levels at birth, previous and present malaria infections as well as exposure to Anopheles bites were significantly associated with the natural acquisition of malaria antibodies in 6- to 18-month old Beninese infants. This study highlighted inescapable factors to consider simultaneously in an immuno-epidemiological study or a vaccine trial in early life.

• 出版日期2016-9-27