A Photorhabdus Natural Product Inhibits Insect Juvenile Hormone Epoxide Hydrolase

作者:Nollmann Friederike I; Heinrich Antje K; Brachmann Alexander O; Morisseau Christophe; Mukherjee Krishnendu; Casanova Torres Angel M; Strobl Frederic; Kleinhans David; Kinski Sebastian; Schultz Katharina; Beeton Michael L; Kaiser Marcel; Chu Ya Yun; Long Phan Ke; Thanwisai Aunchalee; Bozhueyuek Kenan A J; Chantratita Narisara; Goetz Friedrich; Waterfield Nick R; Vilcinskas Andreas; Stelzer Ernst H K; Goodrich Blair Heidi; Hammock Bruce D; Bode Helge B*
来源:ChemBioChem, 2015, 16(5): 766-771.
DOI:10.1002/cbic.201402650

摘要

Simple urea compounds (phurealipids) have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.

  • 出版日期2015-3-23