The Development of FVIII Inhibitors in Relation to IL10 Gene Polymorphism in Hemophilia A Egyptian Pediatric Patients

作者：Sadek Hoda; Youssry Ilham; Ibrahim Nihal Salah Eldeen; Abou Elalla Amany Ahmed; Atef Gehad; Mousa Somaia Mohammed^*

来源：Fetal and Pediatric Pathology, 2017, 36(3): 184-189.

DOI：10.1080/15513815.2017.1281363

• Hemophilia A
• FVIII inhibitors
• IL10 gene polymorphism
• Egypt

Background: Development of inhibitors against Factor VIII (FVIII) in hemophilia A patients is a serious complication of therapy. Many cytokines, including interleukin-10 (IL10), may affect inhibitor development; however, literature data are not sufficient to prove this association. The aim of this study was to investigate the relation between FVIII inhibitor formation and IL10-1082A/G polymorphism among Egyptian hemophiliacs. Methods: Patients were screened for FVIII inhibitors using the Bethesda method. IL10-1082A/G polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism. Results: Six patients (12%) developed inhibitors. No statistically significant difference was found between inhibitor positive and negative patients regarding IL10-1082A/G genotypes, disease severity, or treatment-related variables (type of FVIII received, treatment regimen, age at first exposure to FVIII, and frequency of replacement therapy). Conclusions: FVIII inhibitor formation in this group of Egyptian hemophiliacs was not correlated to IL10-1082A/G polymorphism, disease severity, or any of the treatment variables.

• 出版日期2017