FeCl(3)-Prornoted [3+3] Cycloaddition: Efficient Preparation of 1,2-Dihydro-2-oxo-3-pyridinecarboxylate and 1,2-Dihydro-2-oxo-3-pyridinecarboxamide Derivatives

作者：Li Shuheng^*; Wang Shaozhong

来源：Journal of Heterocyclic Chemistry, 2008, 45(6): 1875-1878.

A facile approach was developed on assembly of the 2-pyridone nucleus by ferric chloride promoted [3+3] cycloaddition in propionic acid. The tandem process involves cyclization of Michael adduct followed by aromatization. Thus, different substituted 1,2-dihydro-2-oxo-3-pyridinecarboxylate and 1,2-dihydro-2-oxo-3-pyridinecarboxamide derivatives were prepared in good yields from various enones with malonamic ester and malonamide, respectively

• 出版日期2008-12
• 单位南京大学