Maintained memory in aging is associated with young epigenetic age

作者：Degerman Sofie; Josefsson Maria; Adolfsson Annelie Nordin; Wennstedt Sigrid; Landfors Mattias; Haider Zahra; Pudas Sara; Hultdin Magnus; Nyberg Lars; Adolfsson Rolf

来源：Neurobiology of Aging, 2017, 55: 167-171.

DOI：10.1016/j.neurobiolaging.2017.02.009

• Epigenetic age
• DNA-methylation
• Episodic memory
• Dementia
• Aging
• Longitudinal study

Epigenetic alterations during aging have been proposed to contribute to decline in physical and cognitive functions, and accelerated epigenetic aging has been associated with disease and all-cause mortality later in life. In this study, we estimated epigenetic age dynamics in groups with different memory trajectories (maintained high performance, average decline, and accelerated decline) over a 15-year period. Epigenetic (DNA-methylation [DNAm]) age was assessed, and delta age (DNAm age - chronological age) was calculated in blood samples at baseline (age: 55-65 years) and 15 years later in 52 age- and gender-matched individuals from the Betula study in Sweden. A lower delta DNAm age was observed for those with maintained memory functions compared with those with average (p = 0.035) or accelerated decline (p = 0.037). Moreover, separate analyses revealed that DNAm age at follow-up, but not chronologic age, was a significant predictor of dementia (p = 0.019). Our findings suggest that young epigenetic age contributes to maintained memory in aging.

• 出版日期2017-7