RETRACTED: Aspirin inhibits growth of ovarian cancer by upregulating caspase-3 and downregulating bcl-2 (Retracted article. See vol. 17, pg. 4742, 2019)

作者：Li, Lin; Mao, Xiaogang; Qin, Xiaomin; Zhou, Min; Xing, Hui^*; Dong, Fan; Jiang, Xiaoyuan; Zhuang, Wenhui

来源：Oncology Letters, 2016, 12(1): 93-96.

DOI：10.3892/ol.2016.4607

• aspirin
• p53S mice
• ovarian cancer
• caspase-3 protein
• bcl-2 protein

The aim of the present study was to investigate the effect and mechanism of different concentrations of aspirin in inhibiting the ovarian cancer of p53N236S gene knock-in mice. In total, 28 male p53S mice, with an age range of 4-6 weeks and weight of 20-25 g were selected. The animals were transplanted with SKOV3 cells to establish subdermal human ovarian cancer. The mice were randomly divided into different groups according to the aspirin concentrations (mmol/l) used, i.e., 0, 1, 2 and 3. Subsequently, intraperitoneal injection was performed once every two days for 3 weeks. The tumor volume, lifetime, tumor cell proliferation inhibition rates, caspase-3 protein and bcl-2 protein expression of the four groups were analyzed and compared. Following aspirin treatment for 1, 2 and 3 weeks, the tumor volume of the 3 mmol/l aspirin group was significantly smaller than the other groups (P<0.05). The higher concentration of aspirin led to a smaller tumor size (P<0.05). The cell proliferation inhibition rate of the 3 mmol/l aspirin group was significantly larger than that of other groups (P<0.05). The relative expression level of caspase-3, bcl-2 protein of the 3 mmol/l aspirin group was significantly improved and reduced, respectively. In conclusion, aspirin can inhibit the growth of ovarian cancer of p53S rats due to its upregulation of the expression of caspase-3 protein and downregulation of the expression of bcl-2 protein.

• 出版日期2016-7
• 单位湖北文理学院; 复旦大学