Antibacterial Properties of 3 H-Spiro[1-benzofuran-2,1 '-cyclohexane] Derivatives from Heliotropium filifolium

作者：Urzua Alejandro^*; Echeverria Javier; Rezende Marcos C; Wilkens Marcela

来源：Molecules, 2008, 13(10): 2385-2393.

DOI：10.3390/molecules13102385

• 3H-spiro[1-benzofuran-2,1 '-cyclohexane] derivatives
• Heliotropium filifolium
• antibacterial properties

A re-examination of cuticular components of Heliotropium filifolium allowed the isolation of four new compounds: 3'-hydroxy-2',2',6'-trimethyl-3H-spiro[1-benzofuran-2,1'- cyclohexane]-5-carboxylic acid (2), methyl 3'-acetyloxy-2', 2', 6'-trimethyl-3H-spiro[1-benzofuran-2,1'-cyclohexane]-5-carboxylate (3), methyl 3'-isopentanoyloxy2', 2', 6'-trimethyl-3H-spiro[1-benzofuran-2,1'-cyclohexane]-5-carboxylate (4) and methyl 3'-benzoyloxy-2', 2', 6'-trimethyl-3H-spiro[1-benzofuran-2,1'-cyclohexane]-5-carboxylate (5). Compounds 2-5 were identified by their spectroscopic analogies with filifolinol (1), and their structures confirmed by chemical correlation with 1. The antimicrobial properties of the compounds were tested against Gram positive and Gram negative bacteria. Some of them proved to be active against Gram positive, but inactive against Gram negative bacteria. In searching for structure-activity relationships from the obtained MIC values, lipophilicity was shown to be an important variable.

• 出版日期2008-10