Assessing the absolute quantitative accuracy of Positron Emission Tomography for Cu-64 using traceable calibrated phantoms

作者：Zimmerman B E^*; Bergeron D E; Edgerton J P

来源：Applied Radiation and Isotopes, 2018, 134: 68-73.

DOI：10.1016/j.apradiso.2017.09.016

• Cu-64
• F-18
• PET-CT
• Positron Emission Tomography
• Quantitative imaging

Using uniform cylindrical phantoms containing calibrated solutions of F-18 and Cu-64, we evaluated for the first time the accuracy with which the activity concentration of Cu-64 can be quantified on an absolute basis using Positron Emission Tomography (with X-ray Computed Tomography, PET-CT). The scanner was first calibrated for F-18 using the manufacturer's calibration protocol and a phantom with an activity concentration value traceable to the U.S. National standard. By using a similarly calibrated F-18 solution phantom, we were able to determine a correction factor that can be applied to the Cu-64 imaging data that gave a result that is consistent with 100% recovery with a combined standard uncertainty of 2%. We also demonstrate how a calibrated, solid phantom containing Ge-68 as a long-lived F-18 surrogate can be used to monitor and transfer the correction factor to other studies.

• 出版日期2018-4