Altered Brain Myelin Sheath Morphology after Rewarming in Situ

作者：Dietrichs E S; Lindal S; Naesheim T; Ingebrigtsen T; Tveita T^*

来源：Ultrastructural Pathology, 2010, 34(2): 82-89.

DOI：10.3109/01913120903398753

• hypothermia
• rewarming
• ultra structure
• myelin damage

In this study cerebral ultrastructure was examined in an in vivo rat model, after rewarming from profound hypothermia (15-13 degrees C). Animals held at 37 degrees C served as controls. After rewarming, brains were examined by electron microscope. Micrographs were taken randomly, analyzed anonymously, and quantified by morphometry. Serum analysis of the stress marker S-100 beta was carried out in identical groups. The most striking findings in rewarmed animals, when compared to controls, were alterations of myelin sheaths (p <.008) and elevated S-100 beta (p <.0001). This indicates that cells in the central nervous system are susceptible to injury in an experimental model of accidental hypothermia and rewarming.</.

• 出版日期2010-4
• 单位河北医科大学