Detection of A beta plaques in mouse brain by using a disaggregation-induced fluorescence-enhancing probe

作者：Lee Yeon Ok; Shin Jung Won; Yi Chunsik; Lee Yun Hak; Sohn Nak Won^*; Kang Chulhun; Kim Jong Seung

来源：Chemical Communications, 2014, 50(43): 5741-5744.

DOI：10.1039/c4cc02011a

We herein report a fluorescence probe 1 capable of detecting water-soluble oligomeric Ab aggregates and A beta fibrils. Upon injection into A beta(42)-challenged mouse brains, probe 1 shows increased fluorescence intensity, indicating its facile binding to extracellular Ab fibrils in brain tissues.

• 出版日期2014