摘要
The beneficial effects of moderate alcohol may differ in aging men versus women.
Cognitive and functional decline and neuropathology were investigated in a cohort of aging men and women with diverse alcohol histories.
Non-demented (Clinical Dementia Rating (CDR) of ae
Moderate drinking men had an attenuated rate of decline compared to rare/never drinkers and women on the MMSE and CDR sum of boxes. In contrast, moderate drinking women had a reduced rate of decline only in the Logical Memory Delayed Recall Test (LMDR) compared to rare/never drinkers and men. Moderate alcohol consumption was associated with a reduction in the incidence of advanced (stages 5-6) Braak NFT stage in men (p < 0.05), with no effect in women.
In this cohort, men experienced a broader range of beneficial effects associated with alcohol. Alcohol's effects may differ in men and women in important ways that suggest a narrower beneficial window.
- 出版日期2018-3