Acute Effects of a Mixed Meal on Arterial Stiffness and Central Hemodynamics in Healthy Adults

作者：Taylor Jennifer L; Curry Timothy B; Matzek Luke J; Joyner Michael J; Casey Darren P^*

来源：American Journal of Hypertension, 2014, 27(3): 331-337.

DOI：10.1093/ajh/hpt211

• aortic pressure
• blood pressure
• hypertension
• mixed meal
• pulse wave velocity
• sympathetic nerve activity
• wave reflection

Elevated central pressures and arterial stiffness are associated with increased peripheral resistance and higher sympathetic nervous system activity. Additionally, consumption of a meal is known to be sympathoexcitatory. However, the acute effects of a meal on aortic wave reflection and stiffness are unknown. Therefore, we tested the hypothesis that aortic wave reflection and stiffness would increase after a meal.
We examined these effects using high-fidelity radial arterial pressure waveforms and carotidfemoral pulse wave velocity measured noninvasively by applanation tonometry before and 60 and 180 minutes after ingestion of a liquid mixed meal (Ensure; 40% of daily energy expenditure) in 17 healthy adults (9 men/8 women; aged 292 years). Additionally, we measured sympathetic activity by microneurography at baseline and up to 60 minutes after the meal.
Although sympathetic activity increased after the meal, both peripheral and central pressures were reduced at 180 minutes from baseline (all P < 0.05). Contrary to our hypothesis, augmentation index (14% 3% vs. 2% 3% vs. 8% 3%), augmentation index normalized for heart rate (8% 3% vs. 3% 3% vs. 3% 3%), augmented pressure (51mm Hg vs. 11mm Hg vs. 31mm Hg), and pulse wave velocity (7.10.2 m/s vs. 6.70.2 m/s vs. 6.70.1 m/s) were substantially reduced at 60 and 180 minutes after the meal (all P < 0.05).
Taken together, our results suggest that a liquid mixed meal acutely decreases central hemodynamics and arterial stiffness in healthy adults, which may be a result of meal-related increases in insulin and/or visceral vasodilation.

• 出版日期2014-3