Additional value of a high sensitive thyroglobulin assay in the follow-up of patients with differentiated thyroid carcinoma

作者：Groen Andries H; Hesselink Marielle S Klein; Plukker John T M; Sluiter Wim J; van der Horst Schrivers Anouk N A; Brouwers Adrienne H; Lentjes Eef G W M; Muller Kobold Anneke C; Links Thera P

来源：Clinical Endocrinology, 2017, 86(3): 419-424.

DOI：10.1111/cen.13180

ObjectiveThyroglobulin (Tg) is an excellent tumour marker, as detectable or increasing Tg levels are highly indicative of persistent or recurrent differentiated thyroid carcinoma (DTC). The clinical value of a highly sensitive (hs)-Tg assay in patients with DTC has not yet been established. The aim of this study was to investigate the additional value of unstimulated hs-Tg measurements (Tg-on) compared to stimulated IRMA-Tg measurements (Tg-off) in the follow-up of patients with DTC.
Design, patients, measurementsWe retrospectively studied patients treated for DTC between 2006 and 2013 and compared hs-Tg and IRMA-Tg measurements. The study group consisted of 99 DTC patients in remission; Tg-on was measured 3 months after remnant ablation and Tg-off 6 months after ablation.
ResultsIn the study group, 44 patients showed a hs-Tg-on <015 g/l (functional sensitivity); of these, 43 had an IRMA-Tg-off measurement <10 g/l, resulting in a negative predictive value of 977% and a positive predictive value of 564%.
ConclusionsThe hs-Tg-on measurement is able to predict patients with an IRMA-Tg-off <10 g/l, and therefore decreases the need for Tg stimulation after ablation.

• 出版日期2017-3