A bestatin-based fluorescent probe for aminopeptidase N cell imaging

作者：Chen, Hui; Wang, Hui; Qin, Xiao-Jun; Chen, Chen; Feng, Lu; Chen, Lai-Zhong; Du, Lu-Pei; Li, Min-Yong^*

来源：Chinese Chemical Letters, 2015, 26(5): 513-516.

DOI：10.1016/j.cclet.2015.01.023

• Aminopeptidase N
• Bestatin
• Cell imaging
• Fluorescent probe

Aminopeptidase N (APN) is an important drug target and biomarker for various tumors. The current work characterizes a novel APN-targeted fluorescent probe (Bes-Green, 2) that manifests comparable inhibitory activity with Bestatin. This probe has capacity of tightly binding to the APN for imaging endogenous APN in living human ovarian clear cell carcinoma cells (ES-2) and has potential application in biological study of cellular APN.

• 出版日期2015-5
• 单位中国药科大学; 山东大学