A novel balloon colonoscope detects significantly more simulated polyps than a standard colonoscope in a colon model

作者:Hasan Nazia; Gross Seth A; Gralnek Ian M*; Pochapin Mark; Kiesslich Ralf; Halpern Zamir
来源:Gastrointestinal Endoscopy, 2014, 80(6): 1135-1140.
DOI:10.1016/j.gie.2014.04.024

摘要

Background: Although standard colonoscopy is considered the optimal test to detect adenomas, it can have a significant adenoma miss rate. A major contributing factor to high miss rates is the inability to visualize adenomas behind haustral folds and at anatomic flexures. %26lt;br%26gt;Objective: To compare the diagnostic yield of balloon-assisted colonoscopy versus standard colonoscopy in the detection of simulated polyps in a colon model. %26lt;br%26gt;Design: Prospective, cohort study. %26lt;br%26gt;Setting: International gastroenterology meeting. %26lt;br%26gt;Subject: A colon model composed of elastic material, which mimics the flexible structure of haustral folds, allowing for dynamic responses to balloon inflation, with embedded simulated colon polyps (n = 12 silicone %26quot; polyps%26quot;). %26lt;br%26gt;Interventions: Fifty gastroenterologists were recruited to identify simulated colon polyps in a colon model, first using standard colonoscopy immediately followed by balloon-assisted colonoscopy. Main Outcome Measurements: Detection of simulated polyps. %26lt;br%26gt;Results: The median polyp detection rate for all simulated polyps was significantly higher with balloon-assisted as compared with standard colonoscopy (91.7% vs 45.8%, respectively; P %26lt; .0001). The significantly higher simulated polyp detection rate with balloon-assisted versus standard colonoscopy was notable both for non-obscured polyps (100.0% vs 75.0%; P %26lt; .0001) and obscured polyps (88.0% vs 25.0%; P %26lt; .0001). %26lt;br%26gt;Limitations: Non-randomized design, use of a colon model, and simulated colon polyps. %26lt;br%26gt;Conclusion: As compared with standard colonoscopy, balloon-assisted colonoscopy detected significantly more obscured and non-obscured simulated polyps in a colon model. Clinical studies in human participants are being pursued to further evaluate this new colonoscopic technology.

  • 出版日期2014-12