Association of altered collagen content and lysyl oxidase expression in degenerative mitral valve disease

作者：Purushothaman K Raman; Purushothaman Meerarani; Turnbull Irene C; Adams David H; Anyanwu Anelechi; Krishnan Prakash; Kini Annapoorna; Sharma Samin K; O'Connor William N; Moreno Pedro R

来源：Cardiovascular Pathology, 2017, 29: 11-18.

DOI：10.1016/j.carpath.2017.04.001

• Degenerative mitral valve disease
• Mitral regurgitation
• Collagen
• Lysyl oxidase
• Valvular interstitial cells
• Extracellular matrix

Abstract(#br)Background(#br)Collagen cross-linking is mediated by lysyl oxidase (LOX) enzyme in the extracellular matrix (ECM) of mitral valve leaflets. Alterations in collagen content and LOX protein expression in the ECM of degenerative mitral valve may enhance leaflet expansion and disease severi...

• 出版日期2017-8
• 单位Icahn School of Medicine at Mount Sinai