Allele-specific associations of 5-HTTLPR/rs25531 with ADHD and autism spectrum disorder

作者：Gadow Kenneth D^*; DeVincent Carla J; Siegal Victoria I; Olvet Doreen M; Kibria Saniya; Kirsch Sarah F; Hatchwell Eli

来源：Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2013, 40: 292-297.

DOI：10.1016/j.pnpbp.2012.10.019

• 5-HTTLPR
• Attention-deficit hyperactivity disorder
• Autism spectrum disorder
• Serotonin
• SLC6A4 gene

Background: The aims of the present study were to examine the association between a common serotonin transporter gene (SLC6A4) polymorphism 5-HTTLPR/rs25531 with severity of attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) symptoms.
Methods: Mothers and teachers completed a validated DSM-IV-referenced rating scale for ADHD and ASD symptoms in 118 children with ASD.
Results: Analyses indicated that children with at least one copy of the S or L-G allele obtained significantly more severe maternal ratings of hyperactivity (p = 0.001; eta p(2) = 0.097) and impulsivity (p = 0.027; eta p(2) = 0.044) but not inattention (p= 0.061; eta p(2) = 0.032), controlling for ASD severity, than children homozygous for the L-A allele. Conversely, mothers' ratings indicated that children with L-A/L-A genotype had more severe ASD social deficits than S or L-G allele carriers (p = 0.003; eta p(2) = 0.081), controlling for ADHD symptom severity. Teachers' ratings though consistent with mothers' ratings of hyperactivity and social deficits were marginally significant (p = 0.07/p = 0.09). There was some evidence that the magnitude of parent-teacher agreement regarding symptom severity varied as a function of the child's genotype.
Conclusion: The 5-HTTLPR/rs25531 polymorphism or its correlates may modulate severity of ADHD and ASD symptoms in children with ASD, but in different ways. These tentative, hypothesis-generating findings require replication with larger independent samples.

• 出版日期2013-1-10