Necrotizing gingivostomatitis and osteonecrosis associated with antithyroid drug propylthiouracil therapy

作者：Xing, Haixia; Guan, Xiaobing^*

来源：Oral Surgery Oral Medicine Oral Pathology Oral Radiology, 2015, 119(2): E65-E68.

DOI：10.1016/j.oooo.2014.11.001

• INDUCED AGRANULOCYTOSIS
• CONGENITAL NEUTROPENIA
• GRAVES-DISEASE

A 43-year-old Chinese female had been diagnosed with hyperthyroidism 15 years ago. She was recently administered 150 mg/day propylthiouracil (PTU). After 3 weeks of PTU administration, she developed necrotizing stomatitis and osteonecrosis, most likely due to secondary effects from the PTU treatment. Her neutrophil count was reduced below normal to 0.24 x 10(9)/L but normalized after withdrawal of PTU therapy. About 1 month after onset, the patient came to our hospital and began to receive intravenous treatments of metronidazole and amoxicillin. Following review of her medical history and a series of clinical and laboratory examinations, the patient was diagnosed with secondary necrotizing gingivostomatitis and osteonecrosis possibly associated with PTU-induced agranulocytosis. One-year after treatment, the patient's oral manifestations remained unchanged. This case demonstrates the need for dental practitioners to more closely monitor oral symptoms in patients with hyperthyroidism treated with antithyroid drugs.

• 出版日期2015-2
• 单位首都医科大学